The act of exhibitionism - the offence of small social mischievousness?

W niniejszej pracy zaprezentowano przypadek 19-letniego ekshibicjonisty. W komentarzu przedstawiono trudności w profilaktyce i leczeniu tej parafilii ze względu na obowiązujący w Polsce system prawny.This paper introduce a case of study of 19-year-old exhibitionist. In commentary author presents a trouble in prevention and treatment that paraphilia by the reason of the polish legal system

The impact of computed high b-value images on the diagnostic accuracy of DWI for prostate cancer: A receiver operating characteristics analysis.

To evaluate the performance of computed high b value diffusion-weighted images (DWI) in prostate cancer detection. 97 consecutive patients who had undergone multiparametric MRI of the prostate followed by biopsy were reviewed. Five radiologists independently scored 138 lesions on native high b-value images (b = 1200 s/mm2), apparent diffusion coefficient (ADC) maps, and computed high b-value images (contrast equivalent to b = 2000 s/mm2) to compare their diagnostic accuracy. Receiver operating characteristic (ROC) analysis and McNemar's test were performed to assess the relative performance of computed high b value DWI, native high b-value DWI and ADC maps. No significant difference existed in the area under the curve (AUC) for ROCs comparing B1200 (b = 1200 s/mm2) to computed B2000 (c-B2000) in 5 readers. In 4 of 5 readers c-B2000 had significantly increased sensitivity and/or decreased specificity compared to B1200 (McNemar's p < 0.05), at selected thresholds of interpretation. ADC maps were less accurate than B1200 or c-B2000 for 2 of 5 readers (P < 0.05). This study detected no consistent improvement in overall diagnostic accuracy using c-B2000, compared with B1200 images. Readers detected more cancer with c-B2000 images (increased sensitivity) but also more false positive findings (decreased specificity)

Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): a randomised, double-blind, phase 3 trial

Few treatments with a distinct mechanism of action are available for patients with platinum-refractory advanced or metastatic urothelial carcinoma. We assessed the efficacy and safety of treatment with docetaxel plus either ramucirumab-a human IgG1 VEGFR-2 antagonist-or placebo in this patient population

THE APPLICATION OF IMAGE ANALYSIS IN NON-INVASIVE RESEARCH

Non-destructive research of historical objects makes possible to collect valuable information concerning technical construction and the state of preservation. Observations and analyses carried out in visible light, UV, infrared as well as under the impact of X-ray radiation provide an image of the object's surface and its inner structure. The outcome obtained in this manner is registered most often in the form of digital photographs. Such a form of recording together with suitable computer techniques create the possibility of systematizing and making informations collected from the photograph more precise. Presented publication deals with the possibility of applying computer analysis techniques into nondestructive studies of works of art. This is an attempt at elaborating a method (or a tool) which will improve the examination of historical objects. The example of three selected objects from the collections of the National Museum in Krakow presents various possibilities of computer analysis as well as its application in suitable research. Such a method could become useful in assessing the state of the preservation of the object as well as its technical structure or manner of execution. The article, of a purely reconnaissance nature, is a collective publication of the Laboratory of Non-Destructive Analysis and Research of Historic Objects of the National Museum in Krakow and the Strata Mechanics Research Institute of the Polish Academy of Sciences in Krakow

Samoistne rozwarstwienie tętnic dogłowowych

Rozwarstwienie tętnicy dogłowowej jest schorzeniem o złożonej etiologii. Ze względu na zmienną symptomatologięi często podostry przebieg prawidłowe rozpoznanie może sprawiać trudności. Autorzy przedstawili przypadek chorejw wieku 32 lat, u której doszło do samoistnego rozwarstwienia t ętnic dogłowowych z pr zemijającymi objawamineurologicznymi

ACR Appropriateness Criteria((R)) Imaging of Mesenteric Ischemia

Mesenteric ischemia is an uncommon condition resulting from decreased blood flow to the small or large bowel in an acute or chronic setting. Acute ischemia is associated with high rates of morbidity and mortality; however, it is difficult to diagnose clinically. Therefore, a high degree of suspicion and prompt imaging evaluation are necessary. Chronic mesenteric ischemia is less common and typically caused by atherosclerotic occlusion or severe stenosis of at least two of the main mesenteric vessels. While several imaging examination options are available for the initial evaluation of both acute and chronic mesenteric ischemia, CTA of the abdomen and pelvis is overall the most appropriate choice for both conditions. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment